L A Liggett

About Me

I am a currently a Postdoctoral Fellow at Boston Children's, Harvard Med, and The Broad Insitute working in human medical genetics in the lab of Vijay Sankaran.

I have my B.S.E. from Case Western Reserve in Biomedical Engineering with a focus in Tissue Engineering, M.S. in Biology from Case Western Reserve, and a Ph.D. in Cell, Stem Cell, and Developmental Biology from The University of Colorado School of Medicine.

Recently I have been trying to understand the processes that underlie tissue evolution within the hematopoietic system during physiological human aging.

These days, I spend my spare time running, losing chess games, and hanging out with that lady on the right.

Publications

Curriculum Vitae

1. LA Liggett, VG Sankaran (2022). Patchwork Cancer Predisposition. Cancer Discovery
2. Fulong Yu, Liam D Cato, Chen Weng, L Alexander Liggett, Soyoung Jeon, Keren Xu, Charleston WK Chiang, Joseph L Wiemels, Jonathan S Weissman, Adam J de Smith, Vijay G Sankaran (2022). Variant to function mapping at single-cell resolution through network propagation. Nature Biotechnology
3. L. Alexander Liggett, Liam D. Cato, Joshua S. Weinstock, Yingze Zhang, Seyed Mehdi Nouraie, Mark T. Gladwin, Melanie E. Garrett, Allison Ashley-Koch, Marilyn J. Telen, Brian Custer, Shannon Kelly, Carla Luana Dinardo, Ester C. Sabino, Paula Loureiro, Anna Bárbara Carneiro-Proietti, Cláudia Maximo, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Alexander P. Reiner, Gonçalo R. Abecasis, David A. Williams, Pradeep Natarajan, Alexander G. Bick, Vijay G. Sankaran (2022). Clonal hematopoiesis in sickle cell disease. The Journal of clinical investigation
4. Liggett, L.A., Galbraith, M.D., Smith, K.P., Sullivan, K.D., Granrath, R.E., Enriquez-Estrada, B., Kinning, K.T., Shaw, J.R., Rachubinski, A.L., Espinosa, J.M., et al. (2021). Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation. Blood Adv. 5, 1791–1796.
5. Liggett, L. Alexander, and Vijay G. Sankaran. "Unraveling hematopoiesis through the lens of genomics." Cell 182.6 (2020): 1384-1400..
6. Alexander Liggett, L., Voit, R.A., and Sankaran, V.G. (2020). Sowing the Seeds of Clonal Hematopoiesis. Cell Stem Cell 27, 195–197..
7. Rozhok, A. I., Silberman, R. E., Higa, K. C., Liggett, L. A., Amon, A., & DeGregori, J. (2020). A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution. Scientific reports, 10(1), 1-10.. pdf
8. L Alexander Liggett, Anchal Sharma, Subhajyoti De, James DeGregori (2019). FERMI: A Novel Method for Sensitive Detection of Rare Mutations in Somatic Tissue. G3. pdf
9. Liggett, L.A., and DeGregori, J. (2017). Changing mutational and adaptive landscapes and the genesis of cancer. Biochim. Biophys. Acta. pdf
10. Aivazidis, S., Coughlan, C.M., Rauniyar, A.K., Jiang, H., Liggett, L.A., Maclean, K.N., and Roede, J.R. (2017). The burden of trisomy 21 disrupts the proteostasis network in Down syndrome. PLoS One 12, e0176307. pdf
11. Sullivan, K.D., Lewis, H.C., Hill, A.A., Pandey, A., Jackson, L.P., Cabral, J.M., Smith, K.P., Liggett, L.A., Gomez, E.B., Galbraith, M.D., et al. (2016). Trisomy 21 consistently activates the interferon response. Elife 5. pdf
12. Broome, A.-M., Ramamurthy, G., Lavik, K., Liggett, A., Kinstlinger, I., and Basilion, J. (2015). Optical imaging of targeted beta-galactosidase in brain tumors to detect EGFR levels. Bioconjug. Chem. 26, 660,668. pdf
13. Broome, A.-M., Lavik, K., Ramamurthy, G., Liggett, L.A., Agnes, R.S., and Basilion, J.P. (2010). Abstract 4341: Tumor imaging via beta-galactosidase fragment complementation with a multifunctional targeted-reporter complex. Cancer Res. 70, 4341,4341.
14. Silva, F., Bederman, I., Liggett, A., and Cabrera, M. (2008). Effects of unloading (HS) and loading (exercise training) on overall work capacity in rats. The FASEB Journal 22, 121,121.

Software

FERMI

FERMI (Fast Extremely Rare Mutation Identification) is a set of tools designed for ultra rare variant detection within deep sequencing of UMI-tagged, amplicon captured genomic DNA.

The full pipeline can be downloaded here or forked on github here.
For installation and usage instructions, see the wiki.

Contact

Feel free to contact me at the above email address, or find me at any of the sites below.

• GitHub
• Instagram
• Linkedin
• Linkedin
• Instagram

Elements

i = 0;

while (!deck.isInOrder()) {
    print 'Iteration ' + i;
    deck.shuffle();
    i++;
}

print 'It took ' + i + ' iterations to sort the deck.';